How can I help my cat adjust to the new cats?

ALMOSTBLIND2007 asked:

4 months ago I adopted 2 cats from the local animal rescue and the cat that has lived here for about 4 years has still not adjusted to these 2 new cats or the 2 addtional ones I adopted 2 months ago. The first cat took refuge downstairs in my rec-room on the coach and will only leave that spot to eat and use the litter box(usually) sometimes I find pee/poop on the coach. I have tried everything from keeping them separated to keeping them in the same room. When any of the 4 new cats(2 are still kittens) go near her she just screams bloody murder. Will she ever adjust or should I consider something else?

Cat and Mouse